Assessment of mediastinal tumors using SUVmax and volumetric parameters on FDG PET/CT

Authors

  • Eku Shimosegawa Department of Molecular Imaging in Medicine, Osaka University Graduate School of Medicine
  • Hiroki Kato Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine
  • Jun Hatazawa Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine
  • Kayako Isohashi Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine
  • Mana Ishibashi Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine
  • Osamu Honda Department of Radiology, Osaka University Graduate School of Medicine
  • Takahiro Morita Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine
Abstract:

Objective(s): This study aimed to evaluate the role of pretreatment SUVmax and volumetric FDG positron emission tomography (PET) parameters in the differentiation between benign and malignant mediastinal tumors. In addition, we investigated whether pretreatment SUVmax and volumetric FDG-PET parameters could distinguish thymomas from thymic carcinomas, and low-risk from high-risk thymomas.Methods: This study was conducted on 52 patients with mediastinal tumors undergoing FDG-PET/CT. Histological examination indicated that 29 mediastinal tumors were benign, and 23 cases were malignant. To obtain quantitative PET/CT parameters, we determined the maximum standardized uptake value (SUVmax), volumetric parameters, metabolic tumor volume (MTV), and total lesion glycolysis (TLG) for primary tumors using SUVmax cut-off value of 2.5. SUVmax, MTV and TLG of benign and malignant tumors were comparedusing the Mann-Whitney U test. Moreover, receiver-operating curve (ROC) analysis was applied to identify the cut-off values of SUVmax, MTV and TLG for the accurate differentiation of benign and malignant tumors. SUVmax, MTV and TLG were compared between thymomas and thymic carcinomas, as well as low-risk and high-risk thymomas.Results: Mean SUVmax, MTV and TLG of malignant mediastinal tumors were significantly higher compared to benign tumors (P

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Journal title

volume 5  issue 1

pages  22- 29

publication date 2017-01-01

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